2417718-25-1
英文名称
2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
CAS
2417718-25-1
分子式
C25H19F3N2O
分子量
420.43
MOL 文件
2417718-25-1.mol
2417718-25-1 结构式
基本信息
英文别名
VT-1042-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
物理化学性质
沸点583.3±50.0 °C(Predicted)
密度1.259±0.06 g/cm3(Predicted)
酸度系数(pKa)13.30±0.46(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
VT-104 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT104 is an analog of VT102, which has improved potency and good oral pharmacokinetics in mice. VT104 prevented palmitoylation of the TEAD1 protein. VT104 showed excellent orally bioavailability and long half-lives, which inhibits tumor growth and also lead to shrinkage of established tumors in preclinical models of human mesothelioma CDX models deficient in functional Merlin.