2426685-25-6

中文名称 2426685-25-6

英文名称 L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-

CAS 2426685-25-6

分子式 C107H150N34O32S2

分子量 2488.7

MOL 文件 2426685-25-6.mol

2426685-25-6 结构式

基本信息物理化学性质常见问题列表

基本信息

英文别名

L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-

物理化学性质

密度1.60±0.1 g/cm3(Predicted)

储存条件-20°C储存

形态Solid

颜色White to off-white

常见问题列表

生物活性

TPP-1 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中，TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。

体外研究

TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The K _D value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1.TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation.

体内研究

TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors.

Animal Model:	5 to 6-week-old female Balb/c nude mice injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector
Dosage:	4 mg/kg
Administration:	Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
Result:	Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.