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24730-31-2

中文名称 表面活性剂SURFACTIN
英文名称 SURFACTIN
CAS 24730-31-2
分子式 C53H93N7O13
分子量 1036.34
MOL 文件 24730-31-2.mol
更新日期 2024/07/09 17:20:34
24730-31-2 结构式 24730-31-2 结构式

基本信息

中文别名
表面活性素
表面活性剂SURFACTIN
英文别名
abs9122
SURFACTIN
surfactin C
Surfactin C1
Surfactin peptide
Biosurfactants Surfactin
surfactin from bacillus subtilis
Cyclo(L-α-aspartyl-D-leucyl-L-leucyl-3-hydroxy-13-methyltetradecanoyl-L-α-glutamyl-L-leucyl-D-leucyl-L-valyl)
所属类别
生物化工:生化试剂

物理化学性质

熔点140-144°C
沸点1268.3±65.0 °C(Predicted)
密度1.037±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度ethanol: 10 mg/mL, clear, slightly yellow
酸度系数(pKa)4.00±0.10(Predicted)
形态粉末
颜色白色至淡黄色
水溶解性Water: 31.25 mg/mL (30.15 mM)
稳定性Stable, but store below 10 C. Incompatible with strong oxidizing agents.

安全数据

WGK Germany3

常见问题列表

生物活性
Surfactin 是一种环状脂肽生物表面活性剂,可介导单价和二价阳离子 (如钙离子) 穿过脂质双层膜的通量。Surfactin 可以作为抗微生物佐剂,具有抗菌,抗真菌,抗支原体和溶血作用。Surfactin 还对多种包膜病毒具有抗病毒活性。
靶点

HSV-1

HSV-2

体外研究

Surfactin can increase the activity of NSC277174 against avian pathogenic Escherichia coli (APEC) in vitro with antimicrobial assays such as minimum inhibitory concentrations (MIC) and fractional inhibitory concentration (FIC). For APEC O78 strain, the MIC of NSC277174 and Surfactin are 1000 ug/ml and >1mg/ml, respectively.

体内研究

In the model of chick infection (inoculation of E.coli ), Surfactin exerts adjuvant effects with NSC277174 against APEC by lowering the numerical value of mortality and liver bacterial loads, and regulating the expression of inflammatory cytokines et al. Surfactin can act as a novel antimicrobial adjuvant with NSC277174 against AEPC infection in chicken.

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