247912-76-1

中文名称脱乙基氯喹二磷酸盐

英文名称 Desethylchloroquine diphosphate salt

CAS 247912-76-1

分子式 C16H25ClN3O4P

分子量 389.82

MOL 文件 247912-76-1.mol

247912-76-1 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

脱乙基氯喹二磷酸盐

英文别名

Desethyl chloroquine diphosphate
Desethylchloroquine diphosphate salt

物理化学性质

储存条件4°C, protect from light, stored under nitrogen

溶解度溶于二甲基亚砜

形态Solid

颜色White to off-white

常见问题列表

生物活性

Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine diphosphate 具有抗疟原虫活性。

靶点

P. falciparum

体内研究

Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.