252003-71-7

中文名称 CP-547632 (hydrochloride)

英文名称 CP-547632 (hydrochloride)

CAS 252003-71-7

分子式 C20H25BrClF2N5O3S

分子量 568.86

MOL 文件 252003-71-7.mol

252003-71-7 结构式

基本信息物理化学性质安全数据 CP-547632 (hydrochloride)价格(试剂级) 常见问题列表

基本信息

中文别名

化合物 T10870

英文别名

CP-547632 HYDROCHLORIDE
CP-547632 hydrochloride >=98% (HPLC)

物理化学性质

储存条件-20°C储存

溶解度DMSO: 38.33 mg/mL (67.38 mM); Water: < 0.1 mg/mL (insoluble)

形态Solid

颜色White to light yellow

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H315-H319-H335

防范说明P305+P351+P338

CP-547632 (hydrochloride)价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/11/08	HY-13302B	CP-547632 (hydrochloride) CP-547632 hydrochloride	252003-71-7	5mg	850元
2024/11/08	HY-13302B	CP-547632 (hydrochloride) CP-547632 hydrochloride	252003-71-7	10mM * 1mLin DMSO	1060元
2024/11/08	HY-13302B	CP-547632 (hydrochloride) CP-547632 hydrochloride	252003-71-7	10mg	1250元

常见问题列表

生物活性

CP-547632 hydrochloride 是一种口服有效的，ATP 竞争性的 VEGFR-2 和 FGF 激酶抑制剂，IC50 分别为 11 nM 和 9 nM。CP-547632 hydrochloride 对 VEGFR2 和 bFGF 的选择性高于 EGFR，PDGFRβ 和相关的酪氨酸激酶 (TKs)。CP-547632 hydrochloride 具有抗肿瘤作用。

靶点

VEGFR-2

11 nM (IC ₅₀ )

FGFR

9 nM (IC ₅₀ )

体外研究

CP-547632 hydrochloride (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC ₅₀ value of 6 nM.

Western Blot Analysis

Cell Line:	Serum-deprived cells
Concentration:	1, 4, 16, 63, 250, 1000 nM
Incubation Time:	1 hours
Result:	Inhibited VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion.

体内研究

CP-547632 hydrochloride (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
CP-547632 hydrochloride (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours.

Animal Model:	Mice bearing tumors (75-150 mm in size)
Dosage:	6.25, 12.5, 25, 50, 100 mg/kg
Administration:	P.o.; daily; 10-24 days
Result:	Caused a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.

Animal Model:	H-ras tumor-bearing mice
Dosage:	50 mg/kg
Administration:	Oral
Result:	A single oral dose of 50 mg/kg yielded plasma concentrations above 500 ng/ml for 12 hours.