253449-04-6
中文名称
WISKOSTATIN
英文名称
1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL
CAS
253449-04-6
分子式
C17H18Br2N2O
分子量
426.15
MOL 文件
253449-04-6.mol
253449-04-6 结构式
基本信息
中文别名
威司他汀化合物WISKOSTATIN
1-(3,6-二溴-9H-咔唑-9-基)-3-(二甲基氨基)-2-丙醇
英文别名
WISKOSTATINWiskostatin - CAS 253449-04-6 - Calbiochem
1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol
3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL
9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(dimethylamino)methyl]-
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol 97%
9H-Carbazole-9-ethanol, 3,6-dibroMo-alpha-[(diMethylaMino)Methyl]-
3,6-Dibromo-9-[3-(dimethylamino)-2-hydroxyprop-1-yl]-9H-carbazole, 3-(3,6-Dibromo-9H-carbazol-9-yl)-N,N-dimethyl-2-hydroxypropylamine
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点153-155
沸点320.2±22.0 °C(Predicted)
密度1.62±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO：可溶10mg/mL，澄清
酸度系数(pKa)14.40±0.20(Predicted)
形态白色固体
颜色白色至米色
稳定性从购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20℃ 下保存长达 3 个月。
应用领域
用途1
一种选择性的N-wasp抑制剂。Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization. Wiskostatin inhibits actin-dependent cellular functions, including migration, transmembrane transport and phagocytosis.