2553217-91-5

中文名称 BSH-IN-1

英文名称 BSH-IN-1

CAS 2553217-91-5

分子式 C25H41FO3

分子量 408.6

MOL 文件 2553217-91-5.mol

2553217-91-5 结构式

基本信息物理化学性质图谱信息常见问题列表

基本信息

中文别名

化合物 T10623
化合物BSH-IN-1

英文别名

BSH-IN-1
BSH IN 1,BSHIN1

物理化学性质

沸点523.9±30.0 °C(Predicted)

密度1.097±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO: 10 mM

酸度系数(pKa)14.79±0.70(Predicted)

形态固体

颜色White to yellow

图谱信息

BSH-IN-1(2553217-91-5)核磁图(¹HNMR)

常见问题列表

生物活性

BSH-IN-1 是一种重组的肠道细菌胆汁盐水解酶 (BSHs) 的有效和共价抑制剂，对 B. longum BSH (革兰氏阳性) 和 B. theta BSH (革兰氏阴性菌) 的 IC50 分别为 108 和 427 nM。

体外研究

BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative ( B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC ₅₀ s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively.

体内研究

BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted.

Animal Model:	C57BL/6 mice
Dosage:	10 mg/kg
Administration:	Single gavage
Result:	Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community.