257930-74-8
中文名称
亚麻木酚素
英文名称
Secoisolariciresinol diglucoside
CAS
257930-74-8
分子式
C32H46O16
分子量
686.7
MOL 文件
257930-74-8.mol
更新日期
2024/10/08 13:31:26
257930-74-8 结构式
基本信息
中文别名
(S,S)-亚麻木酚素 英文别名
β-D-Glucopyranoside, (2S,3S)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediyl bis- 所属类别
天然产物：木脂素物理化学性质
沸点989.2±65.0 °C(Predicted)
密度1.52±0.1 g/cm3(Predicted)
酸度系数(pKa)9.80±0.20(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Secoisolariciresinol diglucoside ((S,S)-SDG) 是全麦亚麻籽中的主要木脂素，具有抗炎，抗氧化，抗诱变，抗微生物，抗肥胖，降血脂和神经保护作用。体外研究
Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals.
Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers.
体内研究
Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation.
| Animal Model: | Hand feeding mice (10 weeks old, male) are injected with TNFα |
| Dosage: | 4 mg/mouse |
| Administration: | P.o. 2 h before i.c. administration of TNFα |
| Result: | Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%. |