260980-89-0
中文名称
260980-89-0
英文名称
PropanaMide,2-hydroxy-2-Methyl-N-[4-nitro-3-(trifluoroMethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)aMino
CAS
260980-89-0
分子式
C13H11F6N3O5
分子量
403.23
MOL 文件
260980-89-0.mol
更新日期
2023/03/20 15:41:25
260980-89-0 结构式
基本信息
中文别名
化合物TOPILUTAMIDE 英文别名
BP766Fluridil
Topilutamide
Fluridil (Topilutamide)
2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-3-(2,2,2-trifluoroacetamido)propanamide
PropanaMide,2-hydroxy-2-Methyl-N-[4-nitro-3-(trifluoroMethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)aMino
(2R)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]propanamide
物理化学性质
熔点144-145 °C
沸点284-289 °C
密度1.588±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 150 mg/mL (372.00 mM)
酸度系数(pKa)10.66±0.46(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Topilutamide 是一种局部非甾体类抗雄激素 (NSAA)。体内研究
Prostate cancer is the most common cancer and one of the leading causes of cancer deaths in men. One of the commonly used approaches to treat metastatic prostate cancer is via first-generation nonsteroidal anti-androgens (NSAAs), namely Flutamide, Nilutamide, Bicalutamide and Topilutamide.