272105-42-7

中文名称地司特泰

英文名称 Disitertide

CAS 272105-42-7

分子式 C68H109N17O22S2

分子量 1580.84

MOL 文件 272105-42-7.mol

更新日期 2024/07/29 15:56:06

272105-42-7 结构式

基本信息物理化学性质地司特泰价格(试剂级) 常见问题列表

基本信息

中文别名

地司特肽
地司特泰
TGF-Β1抑制剂(DISITERTIDE)
L-苏氨酰-L-丝氨酰-L-亮氨酰-L-ALPHA-天冬氨酰-L-丙氨酰-L-丝氨酰-L-异亮氨酰-L-异亮氨酰-L-色氨酰-L-丙氨酰-L-蛋氨酰-L-蛋氨酰-L-谷氨酰胺酰-L-天冬酰胺

英文别名

disitertide
P144 Peptide
TSLDASIIWAMMQN
P144
P144 PEPTIDE
DISITERTIDE, >98%
Disitertide,P144,P144 Peptide, >98%
L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine

物理化学性质

沸点1968.7±65.0 °C(Predicted)

密度1.327

储存条件-20°C储存

溶解度DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)

酸度系数(pKa)3.15±0.10(Predicted)

形态Solid

颜色White to off-white

InChIInChI=1/C68H109N17O22S2/c1-12-32(5)53(85-67(105)54(33(6)13-2)84-64(102)48(30-87)82-56(94)35(8)74-61(99)45(27-51(91)92)79-62(100)43(24-31(3)4)78-63(101)47(29-86)83-65(103)52(71)36(9)88)66(104)80-44(25-37-28-72-39-17-15-14-16-38(37)39)60(98)73-34(7)55(93)75-41(20-22-108-10)58(96)77-42(21-23-109-11)59(97)76-40(18-19-49(69)89)57(95)81-46(68(106)107)26-50(70)90/h14-17,28,31-36,40-48,52-54,72,86-88H,12-13,18-27,29-30,71H2,1-11H3,(H2,69,89)(H2,70,90)(H,73,98)(H,74,99)(H,75,93)(H,76,97)(H,77,96)(H,78,101)(H,79,100)(H,80,104)(H,81,95)(H,82,94)(H,83,103)(H,84,102)(H,85,105)(H,91,92)(H,106,107)/t32-,33-,34-,35-,36+,40-,41-,42-,43-,44-,45-,46-,47-,48-,52-,53-,54-/s3

InChIKeyIUYPEUHIWDMJLM-INGCBPSVNA-N

SMILESC(C1=CNC2=CC=CC=C12)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H](C(=O)O)CC(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@H](O)C |&1:10,14,19,27,35,44,55,56,63,64,71,77,82,90,98,104,106,r|

地司特泰价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2022/09/18	HY-P0118	地司特泰 Disitertide	272105-42-7	5mg	3500元
2022/09/18	HY-P0118	地司特泰 Disitertide	272105-42-7	10mg	5600元
2022/09/18	HY-P0118	地司特泰 Disitertide	272105-42-7	25mg	11500元

常见问题列表

生物活性

Disitertide (P144) TFA 是转化生长因子 TGFβ1 的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide (P144) 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。

体外研究

Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines.

Western Blot Analysis

Cell Line:	Mouse embryo osteoblast precursor MC3T3-E1 cells.
Concentration:	100 μg/mL.
Incubation Time:	4 h.
Result:	Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.

体内研究

Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.

Animal Model:	Human hypertrophic scars were implanted in 60 nude mice.
Dosage:	300 μg/mL was added the Lipogel.
Administration:	Topical application daily administered.
Result:	Successful shedding was achieved in 83,3% of the xenografts.