2730-71-4
中文名称
硫代秋水仙碱
英文名称
thiocolchicine
CAS
2730-71-4
分子式
C22H25NO5S
分子量
415.5
MOL 文件
2730-71-4.mol
更新日期
2023/03/20 15:41:27
2730-71-4 结构式
基本信息
中文别名
硫秋水仙碱硫代秋水仙碱
英文别名
NSC 186301thiocolchicine
thiocholchicine
10-Thiocolchicine
Thiocolchicoside EP Impurity B
10-Demethoxy-10-methylthiocolchicine
(S)-7-Acetylamino-6,7-dihydro-10-methylthio-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one
(S)-7α-Acetylamino-6,7-dihydro-10-(methylthio)-1,2,3-trimethoxybenzo[a]heptalene-9(5H)-one
N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-methylthio-9-oxobenzo[a]heptalen-7-yl]acetamide
(S)-N-(1,2,3-trimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
物理化学性质
熔点193℃
比旋光度D20 -221°
沸点729.1±60.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
储存条件-20°C
溶解度DMSO：可溶10mg/mL，澄清
酸度系数(pKa)14.75±0.40(Predicted)
形态粉末
颜色白色至米色
常见问题列表
生物活性
Thiocolchicine 是秋水仙碱 (HY-16569) 的衍生物，是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂 (IC50=2.5 µM)，竞争性结合微管蛋白 (Ki=0.7 µM)。Thiocolchicine 可以作为 ADC 的毒素分子。体外研究
Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC 50 values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively.Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. It inhibits cell proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells with IC 50 s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells (IC 50 =50 nM).