273727-89-2

中文名称 273727-89-2

英文名称 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-

CAS 273727-89-2

分子式 C23H25NO

分子量 331.45

MOL 文件 273727-89-2.mol

273727-89-2 结构式

基本信息物理化学性质常见问题列表

基本信息

英文别名

1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-

物理化学性质

沸点478.8±28.0 °C(Predicted)

密度1.083±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)7.99±0.50(Predicted)

常见问题列表

生物活性

ZM39923 是一种 JAK3 抑制剂， pIC50 值为 7.1；ZM39923 同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性，IC50 值为 10 nM。

靶点

JAK3

7.1 (pIC ₅₀ )

JAK1

4.4 (pIC ₅₀ )

EGF-R

5.6 (pIC ₅₀ )

Lck

5.0 (pIC ₅₀ )

CDK4

5.0 (pIC ₅₀ )

TGM2

10 nM (IC ₅₀ )

体外研究

ZM39923 is a JAK3 inhibitor, with a pIC ₅₀ of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC ₅₀ , 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC ₅₀ <5.0). ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC ₅₀ of 10 nM, and acts directly on purified TGM2 to inhibit the Ca ²⁺ activated form of TGM2. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells.