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2763910-08-1

中文名称 (S,R,S)-AHPC-六聚乙二醇-氨基盐酸盐
英文名称 (S,R,S)-AHPC-PEG6-NH2(dihydrochloride)
CAS 2763910-08-1
分子式 C36H58ClN5O10S
分子量 788.4
MOL 文件 2763910-08-1.mol
2763910-08-1 结构式 2763910-08-1 结构式

基本信息

中文别名
(S,R,S)-AHPC-六聚乙二醇-氨基盐酸盐
英文别名
(S,R,S)-AHPC-PEG6-NH2(dihydrochloride)
(2S,4R)-1-((S)-23-amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
所属类别
催化剂及助剂:聚合物

应用领域

用途一
KZN10081, also known as (S,R,S)-AHPC-PEG6-NH2 hydrochloride, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker wtih pendant amine for reactivity with a carboxyl group on the target ligand. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment.
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