278605-15-5
中文名称
4-乙炔基-L-苯丙氨酸 HCL
英文名称
4-Ethynyl-L-phenylalanine HCl
CAS
278605-15-5
分子式
C11H11NO2
分子量
189.21
MOL 文件
278605-15-5.mol
278605-15-5 结构式
基本信息
中文别名
4-乙炔基-L-苯丙氨酸 HCL 英文别名
4-Ethynyl-L-phenylalanineL-Phenylalanine, 4-ethynyl-
4-Ethynyl-L-phenylalanine HCl
所属类别
生物化工：丙氨酸类衍生物物理化学性质
沸点343.2±37.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 2.22 mg/mL (11.73 mM)
酸度系数(pKa)2.18±0.10(Predicted)
形态Solid
颜色Off-white to light yellow
常见问题列表
生物活性
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其 Ki 值为 32.6 μM。靶点
Ki: 32.6 μM (TPH)
体外研究
p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
).
体内研究
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.
| Animal Model: | Male Sprague-Dawley rats (200 g) |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |