28325-56-6
28325-56-6 结构式
基本信息
英文别名
Valtrate HDIVHD-valtrate
Isovaleroxyhydroxydidrovaltratum
Isovaleroxyhydroxydihydrovaltrate
Butanoic acid, 3-methyl-2-(3-methyl-1-oxobutoxy)-, [(1S,2'R,4aR,6S,7aS)-6-(acetyloxy)-4a,5,6,7a-tetrahydro-4a-hydroxy-1-(3-methyl-1-oxobutoxy)spiro[cyclopenta[c]pyran-7(1H),2'-oxiran]-4-yl]methyl ester
所属类别
天然产物：环烯醚萜衍生物常见问题列表
生物活性
IVHD-valtrate 是一种活性Valeriana jatamansi 的衍生物，在体内外对人卵巢癌细胞均有抑制作用。IVHD-valtrate 诱导癌细胞凋亡 (apoptosis)，抑制卵巢癌细胞停滞在 G2/M 期。IVHD-valtrate 有潜力成为用于人类卵巢癌研究的一种新的化疗试剂。靶点
IC50: apoptosis
体外研究
IVHD-valtrate inhibits the growth and proliferation of the A2780 and OVCAR-3 ovarian cancer cell lines in a concentration-dependent manner.IVHD-valtrate results in a relatively low cytotoxicity to immortalized non-tumorigenic human ovarian surface epithelial cells (IOSE-144).