286852-20-8

中文名称 Cyclosporin A-Derivative 1 Free base

CAS 286852-20-8

分子式 C65H117N11O14

分子量 1276.69

MOL 文件 286852-20-8.mol

286852-20-8 结构式

基本信息常见问题列表

基本信息

英文别名

Cyclosporin A-Derivative 1 Free base
N-Methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-

常见问题列表

生物活性

Cyclosporin A-Derivative 1 (Free base) 是环孢菌素 A 衍生的结晶中间体，来自专利 WO 2013167703 A1。Cyclosporin A 是一种免疫抑制剂，能够与亲环蛋白结合并抑制钙调磷酸酶。

体外研究

Cyclosporin A-Derivative 1 is a non-immunosuppressive Cyclosporin A derivative. The cyclosporin is acylated on the butenyl-methyl-threonine side chain and then subjected to a ring-opening reaction (the ring opens between the sarcosine and the N-methyl-leucine residues). Cyclosporin A-Derivative 1 is a linear peptide intermediate.