287194-41-6
287194-41-6 结构式
基本信息
中文别名
(+)-DHMEQ2-羟基-N-[(1R,2R,6R)-2-羟基-5-氧代-7-氧杂双环[4.1.0]庚-3-烯-3-基]苯甲酰胺
英文别名
(1R,2R,6R)-DHMEQ(1R,2R,6R)-Dehydroxymethylepoxyquinomicin
2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide
Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-
物理化学性质
熔点184 °C
沸点617.2±55.0 °C(Predicted)
密度1.58±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 35 mg/mL (133.98 mM)
酸度系数(pKa)8.43±0.30(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
(+)-DHMEQ 是一种抗氧化转录因子 Nrf2 的激活剂。(+)-DHMEQ 是 (-)-DHMEQ 的对映体。(+)-DHMEQ 抑制 NF-kB 的活性低于(-)-DHMEQ。靶点
Nrf2
体外研究
(+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay. (+)-DHMEQ also increases the expression of target antioxidant proteins and cancelled reactive oxygen species (ROS)-induced cell death in a neuronal cell line. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.