288847-34-7
![288847-34-7 结构式](/CAS/20210111/GIF/288847-34-7.gif)
基本信息
中文别名
康普立停 A1 二磷酸酯四钠盐 英文别名
CA1POXi-4503 sodium
Tetrasodium A1 Diphosphate
COMBRETASTATIN A-1 PHOSPHATE
TetrasodiuM coMbretastatin A1 diphosphate
Oxi 4503 Combretastatin A-1 phosphate , CA1P
CoMbretastatin A1 diphosphate tetrasodiuM salt
tetrasodium,[3-methoxy-2-phosphonooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate
3-Methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]-1,2-benzenediol bis(dihydrogen phosphate) tetrasodium salt
所属类别
有机原料:芳香烃应用领域
用途一
OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue.