289656-45-7
289656-45-7 结构式
基本信息
2,2-双(4-氟苯)-2-苯乙酰胺
2,2-双(4-氟苯基)-2-苯乙酰胺
4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺
4-氟-ALPHA-(4-氟苯基)-ALPHA-苯基苯乙酰胺
ICA 17043
ICA-17043
ICA 17043
ICA17043
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide
Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-
Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-
4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
物理化学性质
常见问题列表
IC50: 11 nM (Gardos channel)
ICA-17043 is shown to block the Gardos channel of mouse (C57 Black) RBCs with an IC 50 of 50±6 nM. ICA-17043 blocks this increase in cellular hemoglobin concentration in human RBCs in a concentration-dependent fashion.
ICA-17043 (10 mg/kg, p.o.) administration produces a significant decrease in Gardos channel activity measured at day 11 and 21 and is associated with a corresponding increase in red cell K + content without changes in Na + content. ICA-17043 (10 mg/kg, twice a day) induces a significant increase in Hct after 11 days of dosing in the SAD mouse. Senicapoc (30 mg/kg, p.o.) reduces airway hyperresponsiveness, eosinophil numbers in bronchoalveolar lavage taken 48 hours post-allergen challenge, and vascular remodelling in the sheep.