298690-60-5
298690-60-5 结构式
基本信息
RO67-7476
RO-67-7476
(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- Ro 67-7476 | 298690-60-5 | 2mg | 500元 |
| 2024/08/19 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- Ro 67-7476 | 298690-60-5 | 10mM * 1mLin DMSO | 878元 |
| 2024/08/19 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- Ro 67-7476 | 298690-60-5 | 5mg | 1000元 |
常见问题列表
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mGluR1a 60.1 nM (EC 50 ) |
In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5. Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC 50 =163.3 nM). The EC50 value of full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC 50 for calcium mobilization potentiation.Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC 50 value of 17.7 µM.