30286-75-0

中文名称氧托溴铵

英文名称 OXITROPIUM BROMIDE

CAS 30286-75-0

分子式 C19H26BrNO4

分子量 412.32

MOL 文件 30286-75-0.mol

30286-75-0 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

氧托溴铵
溴化氧托溴铵
化合物 T16417
氧托溴铵 EP标准品

英文别名

Ba 253
ba253br
Oxivent
Ventilat
Tersigan
tersigat
oxitropium
ba-253-br-l
Oxitropiumbromid
oxitropiobromuro

所属类别

分析化学：药典标准品和杂质标准品

物理化学性质

熔点203-204° (dec)

比旋光度D21 -25° (c = 2.0 in water)

储存条件Hygroscopic, -20°C Freezer, Under inert atmosphere

溶解度Very soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

形态neat

颜色灰白色至淡黄色

稳定性吸湿性

安全数据

毒性LD50 orl-rat: 2250 mg/kg DRFUD44,117,79

常见问题列表

生物活性

Oxitropium bromide 是毒蕈碱受体拮抗剂。Oxitropium bromide 具有抗胆碱能支气管扩张作用，能用于哮喘和慢性阻塞性肺疾病的研究。

靶点

mAChR

体外研究

Oxitropium bromide is a muscarinic antagonist which blocks musucarinic acetylcholine receptors (mAChR). Incubation with oxitropium bromide of untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro ; however, it causes both types of muscle to be fatigue resistant.

体内研究

Oxitropium bromide inhalation shifts force-frequency curves upward at 2 h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection in vivo . Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance. The increase in resistance induced by histamine, serotonin, leukotriene D4 or antigen is prevented by oxitropium bromide oxitropium bromide. Inhalation of the anticholinergic agent oxitropium bromide at doses of 1.5 μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine.