303727-31-3

中文名称 4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑

英文名称 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

CAS 303727-31-3

分子式 C20H14ClN3O

分子量 347.8

MOL 文件 303727-31-3.mol

更新日期 2024/06/17 17:25:38

303727-31-3 结构式

基本信息物理化学性质安全数据图谱信息 4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑价格(试剂级) 常见问题列表

基本信息

中文别名

RAF激酶抑制剂(L-779450)
2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-4-基)苯酚
4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑

英文别名

450
L-779
CS-1697
L-779450
Raf Kinase Inhibitor IV
2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol
2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol
2-chloro-5-(2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl)phenol
2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-iMidazol-4-yl)phenol
Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-iMidazol-5-yl]-

所属类别

医药中间体：羟基吡啶

物理化学性质

沸点579.8±50.0 °C(Predicted)

密度1.335±0.06 g/cm3(Predicted)

储存条件Sealed in dry,2-8°C

溶解度DMSO:44.67(Max Conc. mg/mL);128.44(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);86.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.35(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.75(Max Conc. mM)

酸度系数(pKa)8.09±0.10(Predicted)

形态粉末

颜色Light yellow to yellow

安全数据

危险性符号(GHS)

GHS06

警示词危险

危险性描述H301-H315-H319-H335

防范说明P280-P301+P310+P330-P304+P340+P312-P305+P351+P338-P337+P313

海关编码2933399990

图谱信息

4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑(303727-31-3)核磁图(¹HNMR)

4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/08/19	HY-12787	4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 L-779450	303727-31-3	5mg	650元
2024/08/19	HY-12787	4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 L-779450	303727-31-3	10mM * 1mLin DMSO	715元
2024/08/19	HY-12787	4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 L-779450	303727-31-3	10mg	1050元

常见问题列表

生物活性

L-779450是一种高效、低纳摩尔的B-raf抑制剂，IC50为10 nM，Kd为2.4 nM。

靶点

Target	Value
B-Raf (Cell-free assay)	2.4 nM(Kd)
B-Raf (Cell-free assay)	10 nM

体外研究

L-779450 (L-779,450) shows a high degree of specificity towards Raf. The only other tested kinase inhibited is p38MAPK, which has a kinase domain structurally related to Raf. L-779450 inhibits anchorage-independent growth of human tumor lines at doses ranging from 0.3 to 2 μM. The effects of L-779450 (L-779,450) on TRAIL sensitivity are investigated here in melanoma cell lines with high TRAIL sensitivity (A-375 and SK-Mel-147), moderate sensitivity (Mel-HO, SK-Mel-13, and SK-Mel-28), and permanent resistance (MeWo, Mel-2a, and SK-Mel-103), as well as in TRAIL-selected cell lines with acquired resistance (A-375-TS and Mel-HO-TS). Despite only moderate direct effects of L-779450 on apoptosis, it strongly enhances TRAIL-induced apoptosis in sensitive melanoma cells and overrules TRAIL resistance in Mel-2a, SK-Mel-103, A-375-TS, and Mel-HO-TS. At 24 hours, 16-35% apoptosis induction is obtained.