3039-71-2
中文名称
U 18666A
英文名称
U 18666A
CAS
3039-71-2
分子式
C25H42ClNO2
分子量
424.06
MOL 文件
3039-71-2.mol
更新日期
2024/08/11 23:03:17
3039-71-2 结构式
基本信息
中文别名
化合物U18666A(3b)-3-[2-(二乙基氨基)乙氧基]-雄甾-5-烯-17-酮盐酸盐
英文别名
U 18666AU18666A,HCl
U18666A - CAS 3039-71-2 - Calbiochem
3BETA-(2-DIETHYLAMINOETHOXY)-ANDROSTENONE HCL
3BETA-(2-DIETHYLAMINOETHOXY)ANDROST-5-EN-17 ONE, HCL
3BETA-(2-DIETHYLAMINO-ETHOXY)ANDROSTENONE HYDROCHLORIDE
(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-onehydrochloride
(3B)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE HYDROCHLORIDE
(3β)-3-[2-(diethylamino)ethoxy]androst-5-en-17-one dihydrochloride
(3BETA)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE DIHYDROCHLORIDE
物理化学性质
熔点195-196.5 °C(lit.)
熔点195-196.5 °C(lit.)
储存条件2-8°C
储存条件2-8°C
溶解度H2O: 9 mg/mL at ≤60 °C
溶解度H2O: 9 mg/mL at ≤60 °C
形态crystalline
颜色white
水溶解性Soluble in water at 10mg/ml
稳定性从购买之日起 2 年内保持稳定。 DMSO 或蒸馏水中的溶液可在 -20°C 下保存长达 1 周。
常见问题列表
生物活性
U18666A (U18) 是一种 intra-cellular cholesterol transport 的抑制剂，可抑制登革热病毒的侵入和复制。靶点
Cholesterol.
体外研究
U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppresse de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication.