306959-01-3
中文名称
N-(1,5-二甲基-3-氧代-2-苯基-2,3-二氢-1H-吡唑-4-基)-3-甲基-1-苯基-1H-噻吩并[2,3-C]吡唑-5-甲酰胺
英文名称
N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
CAS
306959-01-3
分子式
C24H21N5O2S
分子量
443.52
MOL 文件
306959-01-3.mol
更新日期
2024/06/06 18:41:29
306959-01-3 结构式
基本信息
中文别名
化合物MYLS22N-(1,5-二甲基-3-氧代-2-苯基-2,3-二氢-1H-吡唑-4-基)-3-甲基-1-苯基-1H-噻吩并[2,3-C]吡唑-5-甲酰胺
英文别名
MYLS22N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
1H-Thieno[2,3-c]pyrazole-5-carboxamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-methyl-1-phenyl-
常见问题列表
生物活性
MYLS22 是首创的，选择性视神经萎缩 1 (OPA1) 抑制剂。MYLS22 可以靶向内皮细胞 OPA1 减少肿瘤的生长，通过影响 NFkB 活性和血管生成基因表达抑制血管生成。靶点
OPA1
体内研究
MYLS22 (10 mg/kg/die; peritumoral injection; every 2 days for 14 days) causes the tumor growth curtailed mice.
| Animal Model: | 6-week-old C57BL6/J mice with B16F10 melanomas |
| Dosage: | 10 mg/kg/die |
| Administration: | Peritumoral injection; every 2 days for 14 days |
| Result: | Caused the tumor growth curtailed. |