307297-40-1

中文名称 Epitalon acetate

英文名称 Epitalon

CAS 307297-40-1

分子式 C16H26N4O11

分子量 450.4

MOL 文件 307297-40-1.mol

更新日期 2024/06/24 16:00:55

307297-40-1 结构式

基本信息物理化学性质应用领域

基本信息

英文别名

Epithalon Peptide
Epitalon (acetate)
L-ALANYL-L-Α-GLUTAMYL-L-Α-ASPARTYL-GLYCINE
MONOACETATE

物理化学性质

储存条件-20°C储存

溶解度DMF: 1mg/mL; DMSO: 3mg/mL; PBS (pH 7.2): 5mg/mL

形态固体

InChIKeyJZJOFRXDMYAPDF-UQHDSAJHNA-N

SMILESC(=O)(O)C.[C@H](CC(=O)O)(C(=O)NCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)C |&1:4,19,28,r|

应用领域

用途一

Epitalon is a synthetic tetrapeptide with anti-aging properties. Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates. Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice. It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice. Epitalon also stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys.