31098-42-7

中文名称氨磷汀硫化物

英文名称 2-(3-aminopropylamino)ethanethiol

CAS 31098-42-7

分子式 C5H14N2S

分子量 134.24

MOL 文件 31098-42-7.mol

31098-42-7 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

氨磷汀硫化物

英文别名

WR 1065
2-(3-aminopropylamino)ethanethiol
Ethanethiol,2-[(3-aminopropyl)amino]-
N-(2-Mercaptoethyl)-1,3-propanediamine
2-((3-Aminopropyl)amino)ethyl hydrosulfide

物理化学性质

沸点218.6±15.0 °C(Predicted)

密度0.975±0.06 g/cm3(Predicted)

储存条件4°C, protect from light, stored under nitrogen

溶解度DMSO: < 1 mg/mL (insoluble or slightly soluble)

酸度系数(pKa)10.00±0.10(Predicted)

形态固体

颜色白色

水溶解性Water: 250 mg/mL (1862.34 mM)

常见问题列表

生物活性

Amifostine thiol (WR-1065) 是细胞保护剂 Amifostine (HY-B0639) 的活性代谢物。Amifostine thiol 是一种具有辐射防护能力的细胞保护剂。Amifostine thiol 通过 JNK 依赖的信号通路激活 p53。

靶点

p53

体外研究

Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures.
Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation.
Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation.
Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability.
Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment.
Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage.
Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81.
Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.