32385-58-3
中文名称
S-[2-(4(5)-咪唑基)乙基]异硫脲氢溴酸盐
英文名称
IMETIT DIHYDROBROMIDE
CAS
32385-58-3
分子式
C6H12Br2N4S
分子量
332.06
MOL 文件
32385-58-3.mol
更新日期
2024/07/12 16:05:27
![32385-58-3 结构式](/CAS/GIF/32385-58-3.gif)
基本信息
中文别名
IMETIT 氢溴酸盐S-[2-(4(5)-咪唑基)乙基]异硫脲氢溴酸盐
英文别名
IMETIT DIHYDROBROMIDEVUF 8325 dihydrobromide
SKF 91105 dihydrobromide
S-[2-(Imidazol-4-yl)ethyl]isothiourea2HBr
IMETIT DIHYDROBROMIDE POTENT AND SELECTI VE
5-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
S-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide
CarbaMiMidothioic acid, 2-(1H-iMidazol-4-yl)ethyl ester, dihydrobroMide
物理化学性质
储存条件Store at RT
溶解度H2O: soluble
溶解度可溶于水中
形态solid
颜色off-white
水溶解性Freely soluble in water, practically insoluble in acetone
/n
常见问题列表
生物活性
Imetit dihydrobromide (VUF 8325 dihydrobromide) 是组胺 H3 和 H4 受体的高亲和力的强激动剂,Ki 值分别为 0.3 和 2.7 nM。Imetit dihydrobromide 模拟组胺对嗜酸性粒细胞形状改变的作用 (EC50=25 nM)。靶点
H 3 Receptor 0.3 nM (Ki) |
H 4 receptor 2.7 nM (Ki) |
体内研究
Imetit dihydrobromide (2.5-10 mg/kg; i.p.) reduces the licking response induced by Apomorphine.
Animal Model: | Male Sprague-Dawley rats |
Dosage: | 2.5, 5, 10 mg/kg |
Administration: | i.p. (30 min before Apomorphine) |
Result: | Reduced the licking response induced by Apomorphine. |