324523-20-8

中文名称 2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐

英文名称 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride

CAS 324523-20-8

分子式 C24H26Cl2N2O2

分子量 445.38

MOL 文件 324523-20-8.mol

324523-20-8 结构式

基本信息物理化学性质安全数据图谱信息常见问题列表

基本信息

中文别名

NPS2143盐酸盐
2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐

英文别名

NPS-2143 HCL
NPS-2143 (Mono HCl)
NPS2143
NPS 2143 HCL
SB-262470-A hydrochloride
NPS2143 hydrochloride, >=98%
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1)

物理化学性质

储存条件2-8°C

溶解度二甲基亚砜：>10mg/mL

形态粉末

颜色白色至米色

旋光性 (optical activity)[α]20/D +20 to +24°, c = 1.0 in methanol

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07,GHS09

警示词警告

危险性描述H302+H312+H332-H410

防范说明P261-P273-P280-P301+P312-P302+P352+P312-P304+P340+P312

危险品标志Xn,N

危险类别码20/21/22-50/53

安全说明36/37-60-61

危险品运输编号UN 3077 9 / PGIII

WGK Germany3

图谱信息

2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐(324523-20-8)核磁图(¹HNMR)

常见问题列表

生物活性

NPS-2143 hydrochloride (SB-262470A hydrochloride)，口服活性溶钙剂，是选择性的钙敏感受体 (CaSR) 拮抗剂。NPS-2143 hydrochloride (SB-262470A hydrochloride) 通过激活表达人 Ca2+ 受体的 HEK 293 细胞中的 Ca2+ 受体而引起的胞浆 Ca2+ 浓度增加 (IC50=43 nM)。

体外研究

NPS-2143 hydrochloride (SB-262470A hydrochloride) stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC ₅₀ of 41 nM. Moreover, NPS-2143 hydrochloride also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation.

体内研究

When infused intravenously in normal rats, NPS-2143 hydrochloride (SB-262470A hydrochloride) causes a rapid and large increase in plasma levels of PTH. Ca ²⁺ receptor antagonists are termed calcilytics and NPS-2143 is the first substance (either atomic or molecular) shown to possess such activity.
When administered together with an antiresorptive agent (estradiol), NPS 2143 causes an increase in trabecular bone volume and bone mineral density in osteopenic rats.