32502-62-8
32502-62-8 结构式
基本信息
Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,3,6-trimethyl-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-111117 | 3-methyl toxoflavin 3-Methyltoxoflavin | 32502-62-8 | 5mg | 1330元 |
| 2024/08/19 | HY-111117 | 3-methyl toxoflavin 3-Methyltoxoflavin | 32502-62-8 | 10mM * 1mLin DMSO | 1463元 |
| 2024/08/19 | HY-111117 | 3-methyl toxoflavin 3-Methyltoxoflavin | 32502-62-8 | 10mg | 2000元 |
常见问题列表
IC50: 170 nM (PDI).
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC 50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy. Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis.