329221-38-7
中文名称
AX 20017
英文名称
AX 20017
CAS
329221-38-7
分子式
C13H16N2O2S
分子量
264.34
MOL 文件
329221-38-7.mol
更新日期
2025/02/12 10:44:51
329221-38-7 结构式
基本信息
中文别名
化合物AX200172-(环丙烷甲酰氨基)-4,5,6,7-四氢苯并[B]噻吩-3-甲酰胺
英文别名
AX 20017PknG Inhibitor
AX-20017
AX 20017
2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Benzo[b]thiophene-3-carboxamide, 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-
物理化学性质
储存条件Keep in dark place,Inert atmosphere,2-8°C
溶解度DMSO : ≥ 32 mg/mL (121.06 mM)
形态Solid
颜色White to off-white
AX 20017价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-14987 | AX 20017 AX20017 | 329221-38-7 | 5mg | 500元 |
| 2025/02/08 | HY-14987 | AX 20017 AX20017 | 329221-38-7 | 10mM * 1mLin DMSO | 672元 |
| 2025/02/08 | HY-14987 | AX 20017 AX20017 | 329221-38-7 | 10mg | 700元 |
常见问题列表
生物活性
AX20017是蛋白激酶G (PknG) 的小分子抑制剂，IC50 值为 0.39 μM。靶点
IC50: 0.39 μM (PknG)
体外研究
The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.