329349-20-4

中文名称 1-(3,6-二溴-9H-咔唑-9-基)-3-(哌嗪-1-基)丙-2-醇二盐酸盐

英文名称 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

CAS 329349-20-4

分子式 C19H22Br2ClN3O

分子量 503.66

MOL 文件 329349-20-4.mol

329349-20-4 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

1-(3,6-二溴-9H-咔唑-9-基)-3-(哌嗪-1-基)丙-2-醇二盐酸盐

英文别名

1-(3,6-dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol dihydrochloride

物理化学性质

溶解度Soluble to 5 mM in water and to 100 mM in DMSO

形态Solid

颜色White to off-white

应用领域

用途一

BAI1 is an allosteric inhibitor of Bax channel activation. It binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation. It also selectively inhibits Bax-dependent apoptosis and is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.