331862-41-0
中文名称
331862-41-0
英文名称
IMR-1A
CAS
331862-41-0
分子式
C13H11NO5S2
分子量
325.36
MOL 文件
331862-41-0.mol
更新日期
2024/03/06 11:25:44
331862-41-0 结构式
基本信息
中文别名
化合物IMR-1ANOTCH抑制剂(IMR-1A)
英文别名
IMR-1AIMR-1A, >98%
IMR1A
IMR 1A
IMR-1A
Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
所属类别
生物化工：激动剂抑制剂物理化学性质
密度1.55±0.1 g/cm3(Predicted)
储存条件Inert atmosphere,2-8°C
溶解度DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM)
酸度系数(pKa)3.10±0.10(Predicted)
形态Solid
颜色Light yellow to yellow
常见问题列表
生物活性
IMR-1A 是IMR-1的酸性代谢产物，是一种 Notch 的有效的抑制剂，IC50值为0.5 μM，Kd值为2.9 μM。IMR-1A 具有抗肿瘤活性。靶点
| Target | Value |
|
Notch
(Cell-free assay) | 0.5 μM |
|
Notch
(Cell-free assay) | 2.9 μM(Kd) |
体内研究
IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.
| Animal Model: | Male C57 BL/6 mice |
| Dosage: | 2 mg/kg (i.v.) and 100 mg/kg (i.p) |
| Administration: | I.v. and i.p. |
| Result: | Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration. |