34633-34-6

Androgen Receptor

The absorption, distribution and excretion of Bifluranol have been studied in mouse, rat, ferret and dog; Bifluranol is readily absorbed following oral administration, but blood concentrations of Bifluranol are low due to hepatic uptake and biliary excretion. After intravenous administration of [ ³ H]Bifluranol to rats (200 μg/kg) and ferrets (60 μg/kg) the blood concentrations of ³ H decreases rapidly for the first 2 to 3 h, with the decrease being more rapid in females ( 18 min for rat, 30 min for ferret) than males (1.0 h for rat, 1.4 h for ferret). This is followed by a much slower decline (40 h for rat, 20 h for ferret) to concentrations at 96 h of less than 15 ng Bifluranol equivalents mL ^-1 (rat) or 1 ng Bifluranol equivalents mL ^-1 (ferret).