35865-33-9
35865-33-9 结构式
基本信息
中文别名
猎神霉素KURASOIN
化合物DIANEMYCIN
英文别名
Nsc138320dianemycin
Nanchangmycin free acid
Nanchangmycin >=98% (HPLC)
6-Nonenoic acid, 8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5...
物理化学性质
沸点700.37°C (rough estimate)
密度1.0559 (rough estimate)
折射率1.6130 (estimate)
储存条件-20°C储存
溶解度DMSO: 155 mg/mL (178.75 mM); Water: < 0.1 mg/mL (insoluble)
酸度系数(pKa)4.59±0.21(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Dianemycin (Nanchangmycin free acid) 由 Streptomyces nanchangensis NS3226 产生的一种聚醚抗生素，抑制革兰氏阳性菌。Nanchangmycin 也是一种抗 Zika 病毒的广谱抗病毒药物。靶点
Bacteria
Zika virus
体外研究
Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria.
Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC
50
s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types.