36190-95-1
中文名称
3'-O-METHYLOROBOL
英文名称
3''-METHOXYOROBOL
CAS
36190-95-1
分子式
C16H12O6
分子量
300.26
MOL 文件
36190-95-1.mol
36190-95-1 结构式
基本信息
中文别名
3'-O-甲基香豌豆苷元 英文别名
-O-Methylorobol3'-Methoxy-4',5,7-trihydroxyisoflavone
5,7-Dihydroxy-3-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxy-3-methoxyphenyl)-
所属类别
天然产物：黄酮类化合物应用领域
用途一
3''-Methoxy-4'',5,7-trihydroxyisoflavone is a derivative of Genistein (G350000); a compound that exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2.