368860-21-3
CAS
368860-21-3
分子式
C14H20ClN3O3.C6H8O7
368860-21-3 结构式
常见问题列表
生物活性
Arimoclomol citrate (BRX-220 citrate) 是一种热休克蛋白 (HSP) 的共诱导剂。Arimoclomol citrate 通过增强 Hsp 表达来保护运动神经元，从而通过泛素-蛋白酶体系统直接影响蛋白质聚集及清除错误折叠和装配的蛋白。靶点
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HSP
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体内研究
Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis.
| Animal Model: | Male Wistar rats weighing 240 to 270 g |
| Dosage: | 20 mg/kg |
| Administration: | Administered intragastrically, for 5 days |
| Result: | Had a protective effect against CCK-induced acute pancreatitis. |