37000-20-7
中文名称
净特罗
英文名称
N-(2-HYDROXY-5-(1-HYDROXY-2-(2-METHYL-1-PHENYLPROPAN-2-YLAMINO)ETHYL)PHENYL)METHANE
CAS
37000-20-7
分子式
C19H26N2O4S
分子量
378.49
MOL 文件
37000-20-7.mol
37000-20-7 结构式
基本信息
中文别名
净特罗 英文别名
MJ 9184Zinterol
N-{5-[2-(1,1-DiMethyl-2-phenyl-ethylaMino)-1-hydroxy-ethyl]-2-hydroxy-phenyl}-MethaesulfonaMide
Methanesulfonamide, N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-
N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamidehydrochloride
物理化学性质
沸点574.3±60.0 °C(Predicted)
密度1.282±0.06 g/cm3(Predicted)
储存条件Store at +4°C
溶解度Soluble to 5 mM in water and to 100 mM in DMSO
酸度系数(pKa)8.57±0.50(Predicted)
形态Powder
颜色White to off-white
净特罗价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2023/03/20 | HY-14304 | 净特罗 Zinterol | 37000-20-7 | 1mg | 1550元 |
| 2023/03/20 | HY-14304 | 净特罗 Zinterol | 37000-20-7 | 10mM * 1mLin DMSO | 3872元 |
| 2023/03/20 | HY-14304 | 净特罗 Zinterol | 37000-20-7 | 5mg | 4650元 |
常见问题列表
生物活性
Zinterol (MJ 9184) 是一种有效的选择性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂。Zinterol 增强 ICa，EC50 为 2.2 nM。靶点
β2-adrenoceptor
体内研究
Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits.
| Animal Model: | In New Zealand White HF rabbits of either sex |
| Dosage: | 1.0 or 2.5 μg/kg |
| Administration: | Intravenous bolus administration; over 5 seconds |
| Result: |
2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |