376638-65-2
中文名称
376638-65-2
英文名称
BVT-14225
CAS
376638-65-2
分子式
C16H20ClN3O3S2
分子量
401.93
MOL 文件
376638-65-2.mol
更新日期
2024/09/18 11:55:38
376638-65-2 结构式
基本信息
中文别名
化合物BVT142252-(2-(3-氯-2-甲苯磺酰胺基)噻唑-4-基)-N,N-二乙酰氨
英文别名
BVT-14225BVT-14225, >98%
BVT14225
BVT 14225
4-Thiazoleacetamide,2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点586.5±60.0 °C(Predicted)
密度1.373±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 27 mg/mL (67.18 mM)
酸度系数(pKa)6.34±0.10(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
BVT-14225是选择性的11β羟基类固醇脱氢酶1型(11β-HSD1)抑制剂，IC50值为52 nM。靶点
IC50: 52 nM (11β-HSD1)
体外研究
Selective inhibition of 11β-HSD1 decreases blood glucose concentrations in hyperglycaemic mice. Selective inhibitors of 11β-HSD1 have considerable potential as treatments for a number of diseases of great unmet medical need such as type 2 diabetes, obesity and metabolic syndrome, a multifactorial disorder. BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC 50 for 11β-HSD1 on a human enzyme assay of 52 nM.