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38213-69-3

中文名称 双(麦芽醇)氧钒(IV)
英文名称 Bis(maltolato)oxovanadium(IV)
CAS 38213-69-3
分子式 C12H10O7V
分子量 317.15
MOL 文件 38213-69-3.mol
更新日期 2023/03/20 15:41:17
38213-69-3 结构式 38213-69-3 结构式

基本信息

中文别名
双(麦芽醇)氧钒(IV)
英文别名
BMOV
BIS(MALTOLATO)OXOVANADIUM
BIS(MALTOLATO)OXOVANADIUM(IV)
oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate)
(SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM
Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-
所属类别
原料药

物理化学性质

熔点>300°C (dec.)
储存条件Refrigerator
溶解度DMSO(少许)、甲醇(少许)、水(少许)
形态粉末
颜色黄色到灰色到棕色
LogP0.079 (est)

安全数据

危险性符号(GHS)
GHS06
警示词危险
危险性描述H301
防范说明P301+P310
危险品运输编号UN 2811 6.1 / PGIII
WGK Germany3

常见问题列表

生物活性
BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV))是一种有效的口服钒复合物,具有抗糖尿病特性和模仿胰岛素的作用。BMOV被证明可改善糖尿病模型的心脏功能障碍。
靶点

IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)

体外研究

Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells.

体内研究

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice.

Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)
Dosage: 0.75-3.0 mmol
Administration: Intraperitoneal injection; twice weekly; for 6 weeks
Result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
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