3862-25-7
基本信息
7Α-羟基- 4 -胆固醇-3 -酮
7Α-HYDROXY-4-CHOLESTEN-3-ONE
7Α-HYDROXYCHOLESTENONE
7HCO
ALPHA-HC
Α-HC
alpha-HC
7α-hydroxycholestenone
7a-Hydroxy-cholestene-3-one
7-Hydroxy-4-cholesten-3-one
7a-Hydroxycholest-4-en-3-one
7a-Hydroxy-4-cholesten-3-one
(7a)-7-Hydroxycholest-4-en-3-one
7alpha-hydroxycholest-4-en-3-one
7 alpha-hydroxy-4-cholesten-3-one
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-113259 | 7-羟基-4-胆甾烯-3-酮 7α-Hydroxy-4-cholesten-3-one | 3862-25-7 | 1mg | 3500元 |
常见问题列表
Endogenous Metabolite
Pregnane X receptor (PXR)
7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids (e.g. chenodeoxycholic acid). The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by 3β-hydroxy steroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one.
7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm.