39746-25-3
中文名称
16,16-DIMETHYL PROSTAGLANDIN E2
英文名称
16,16-DIMETHYL PROSTAGLANDIN E2
CAS
39746-25-3
分子式
C22H36O5
分子量
380.52
MOL 文件
39746-25-3.mol
39746-25-3 结构式
基本信息
中文别名
化合物 T1004616,16-二甲基前列腺素E2
英文别名
15r)-13eopentyl)-
16,16-dimethyl-pge2
QAOBBBBDJSWHMU-WMBBNPMCSA-N
16,16-Dimethyl dinoprostone
Suppliedasayellow,viscousoil
16,16-DimethylprostaglandineE2
16,16-DIMETHYL PROSTAGLANDIN E2
16,16-Dimethylprostaglandin E2 methyl acetate solution
16,16-DIMETHYL PROSTAGLANDIN E2 SUPPLIED AS A YELLOW, VISCOUS OIL
所属类别
医药中间体：原料药中间体物理化学性质
闪点-13℃
储存条件-20°C
溶解度Soluble in methyl acetate
形态methyl acetate solution
颜色Colorless to light yellow
安全数据
警示词危险
危险性描述H225-H319-H336
危险品标志F,Xn,Xi
安全说明16-26-36
危险品运输编号UN 1231 3/PG 2
危险品运输编号UN 1231 3/PG 2
WGK Germany3
WGK Germany3
常见问题列表
生物活性
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) 是一种具有口服活性的脊椎动物造血干细胞 (HSCs) 稳态关键调节剂。16,16-Dimethyl prostaglandin E2 可以通过 EP2/EP4 起作用，并与 Wnt 途径相互作用。靶点
|
EP2
|
EP4
|
体内研究
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2; 10 µg/kg; i.p.; every 12 hours; for 8 days) rescues the exacerbated DSS colitis phenotype of Tpl2 IMF-KO mice and restores epithelial proliferation and structure.
| Animal Model: | Tpl2 IMF-KO mice |
| Dosage: | 10 µg/kg |
| Administration: | IP; every 12 hours; for 8 days |
| Result: | Rescued the exacerbated DSS colitis phenotype and restores epithelial proliferation and structure. |