41179-33-3
中文名称
CMPD1
英文名称
2'-FLUORO-N-(4-HYDROXYPHENYL)-[1,1'-BIPHENYL]-4-BUTANAMIDE
CAS
41179-33-3
分子式
C22H20FNO2
分子量
349.4
MOL 文件
41179-33-3.mol
41179-33-3 结构式
基本信息
中文别名
化合物CMPD14-(2'-氟-[1,1'-联苯]-4-基)-N-(4-羟基苯基)丁酰胺
英文别名
SRA1CMD1
CMPD-1
MK2a Inhibitor
CMPD-1 (CMPD 1
Steroid receptor RNA activator 1
ANTI-SOX9 antibody produced in mouse
MK2a Inhibitor - CAS 41179-33-3 - Calbiochem
ANTI-SRA1 (C-TERM) antibody produced in rabbit
Monoclonal Anti-SOX9 antibody produced in mouse
物理化学性质
熔点128-130 °C
沸点585.0±50.0 °C(Predicted)
密度1.229±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度Soluble to 100 mM in DMSO and to 100 mM in ethanol
酸度系数(pKa)10.11±0.26(Predicted)
形态淡黄色固体
颜色Off-white to light brown
常见问题列表
生物活性
CMPD1 是一种选择性且非 ATP 竞争性的 p38 MAPK 介导的 MK2 磷酸化抑制剂，表观 Ki (Kiapp) 值为 330 nM。靶点
Ki app : 330 nM (MK2 phosphorylation)
体外研究
CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2.
CMPD1 induced mitotic arrest and apoptosis in U87 cells.
CMPD1 inhibits tubulin polymerisation in glioblastoma cells.