41544-24-5

中文名称 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride

英文名称 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride

CAS 41544-24-5

分子式 C16H28N2O2.ClH

分子量 316.867

MOL 文件 41544-24-5.mol

41544-24-5 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

盐酸曲金刚胺

英文别名

Virumerz
Viruserol
Viru-merz
Einecs 255-434-5
Tromantadine HCl
Tromantadin hydrochlorid
2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride

物理化学性质

熔点157-158°

形态Solid

颜色White to off-white

安全数据

毒性LD50 orally in rats: 630 mg/kg; i.v. in mice: 71.0 mg/kg (Peteri, Sterner)

常见问题列表

生物活性

Tromantadine hydrochloride，Amantadine 衍生物，具有抗疱疹活性，可抑制单纯疱疹病毒1型 (HSV-1) 和 HSV-2 的复制。

靶点

HSV-1

HSV-2

体外研究

Treatment of the cells with 10 to 50μg of Tromantadine reduces HSV-induced cytopathic effect. Treatment with 100 to 500μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection.