420831-40-9
420831-40-9 结构式
基本信息
CS-922
AK 7, >=98%
AK-7
AK7
AK 7
SIRT2 Inhibitor II
SIRT2 Inhibitor,AK-7
SIRT2 Inhibitor II, AK-7
SIRT2 INHIBITOR II
AK7
AK 7
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
物理化学性质
常见问题列表
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SIRT2 15.5 μM (IC 50 ) |
AK-7 (10 μM) reduces cholesterol levels in naive N2a neuroblastoma cells and hippocampal slice cultures from wild-type mice. AK-7 (1 μM) shows neuroprotective effect of AK-7 in striatal Huntington’s disease (HD) neurons. AK-7 (12.5 μM) decreases ratio of DA neurons in primary midbrain cultures.
AK-7 (15 mg/kg/dose, i.p.) is brain-permeable in wild-type and HD mice. AK-7 (10, 20 mg/kg, i.p.) improves the behavior and neuropathological phenotype and extends survival of R6/2 HD mice. AK-7 (20 mg/kg) ameliorates HD neuropathology in R6/2 mice. AK-7 also reduces the polyglutamine aggregation in R6/2 brain. In addition, AK-7 treated 140CAG mice show motor performance changes that parallel untreated wild-type mice, with the 20 mg/kg dose being most effective and significantly different from untreated 140CAG mice.