42373-41-1
42373-41-1 结构式
基本信息
中文别名
腺苷三磷酸二钾盐5'-三磷酸腺苷二钾盐
腺苷-5'-三磷酸二钾盐
二水合-5`-三磷酸腺苷二钾盐
英文别名
ATP·K25'-ATP-K2
ATP dipotassium
ATP POTASSIUM SALT
ADENOSINE 5'-TRIPHOSPHATE POTASSIUM SALT
ADENOSINE-5'-TRIPHOSPHATE DIPOTASSIUM SALT
adenosine 5'-triphosphate dipotassium*from bacter
ADENOSINE 5'-TRIPHOSPHATE DIPOTASSIUMFRO M BACTERIA
Adenosine 5μ-triphosphate dihydrate dipotassium salt
Adenosine 5'-(tetrahydrogen triphosphate), dipotassiuM salt
常见问题列表
生物活性
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP dipotassium 是免疫和炎症中重要的内源性信号分子。体外研究
ATP dipotassium (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.
ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.
ATP dipotassium promotes neutrophil chemotaxis in vitro.
体内研究
ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.
ATP dipotassium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo.
| Animal Model: | Four-week-old Kunming mice (18-22 g) |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection, before bacterial ( E. coli ) challenge |
| Result: | Protected mice from bacterial infection. |