440645-08-9
中文名称
Α-突刺蛋白61-75
英文名称
L-Threonine, L-α-glutamyl-L-glutaminyl-L-valyl-L-threonyl-L-asparaginyl-L-valylglycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl-
CAS
440645-08-9
分子式
C60H103N17O23
更新日期
2025/07/03 08:59:58
分子量
1430.58
MOL 文件
440645-08-9.mol
440645-08-9 结构式
基本信息
中文别名
Α-突刺蛋白61-75 英文别名
α-Synuclein (61-75)L-Threonine, L-α-glutamyl-L-glutaminyl-L-valyl-L-threonyl-L-asparaginyl-L-valylglycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl-
常见问题列表
生物活性
α-Synuclein (61-75) 是 α-Synuclein 的 61-75 片段。α-Synuclein 是一种丰富的神经元蛋白，在突触前神经末梢高度丰富。α-Synuclein 是一种帕金森氏病 (PD) 的生物标志物。体外研究
Lewy bodies containing α-Synuclein are a neuropathological hallmark of PD, and missense mutations in α-Synuclein (A30P, E46K, H50Q, G51D, A53E, A53T), as well as α-Synuclein gene duplications and triplications, appear to cause PD. Moreover, polymorphisms in regulatory elements of the α-Synuclein gene predispose individuals to PD and are linked to an early onset of the disease. The non-Aβ-amyloid component (NAC) region of α-synuclein is relatively hydrophobic and aggregation-prone in human α-Synuclein but not in mouse α-Synuclein nor in the corresponding homologous region of human β-synuclein. Yet, β-synuclein is more homologous to α-synuclein in the N-terminal sequences (74%) than γ-synuclein (67%).