453590-24-4

中文名称 6-(4-甲氧基苯基)呋喃并[2,3-D]嘧啶-4-胺

英文名称 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE

CAS 453590-24-4

分子式 C13H11N3O2

分子量 241.25

MOL 文件 453590-24-4.mol

453590-24-4 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T8817
6-(4-甲氧基苯基)呋喃并[2,3-D]嘧啶-4-胺

英文别名

Kinase IN-1
TIE-2/VEGFR-2 kinase-IN-1
6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamine

物理化学性质

沸点450.4±45.0 °C(Predicted)

密度1.308±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO: 5 mg/mL (20.73 mM; ultrasonic and warming and heat to 80°C)

酸度系数(pKa)4.73±0.40(Predicted)

形态Solid

颜色Yellow to brown

常见问题列表

生物活性

TIE-2/VEGFR-2 kinase-IN-1 用于合成 TIE-2 或者 VEGFR-2 抑制剂，从专利 WO2003022852 中获得，例 14。TIE-2/VEGFR-2 kinase-IN-1 用于研究不适当的血管生成相关疾病。

体外研究

Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor.Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis.