460330-27-2
中文名称
GT 949
英文名称
GT 949
CAS
460330-27-2
分子式
C30H37N7O2
分子量
527.66
MOL 文件
460330-27-2.mol
更新日期
2024/08/29 09:35:13
460330-27-2 结构式
基本信息
中文别名
化合物GT 949化合物 T15446
英文别名
GT 9493-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-
物理化学性质
沸点770.7±60.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 100 mM; Ethanol: 10 mM, heated
酸度系数(pKa)10.55±0.70(Predicted)
形态固体
颜色Off-white to light yellow
GT 949价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-114381 | GT 949 GT 949 | 460330-27-2 | 5mg | 800元 |
| 2024/08/19 | HY-114381 | GT 949 GT 949 | 460330-27-2 | 10mg | 1400元 |
| 2024/08/19 | HY-114381 | GT 949 GT 949 | 460330-27-2 | 25mg | 2800元 |
常见问题列表
生物活性
GT 949 是一种选择性的兴奋性氨基酸转运蛋白-2 (EAAT2) 阳性变构调节剂，EC50 为 0.26 nM。靶点
EC50: 0.26±0.03 nM (EAAT2)
体外研究
GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3.
GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in V
max
of about 47%.