473268-46-1
中文名称
473268-46-1
英文名称
ADDA 5 hydrochloride
CAS
473268-46-1
更新日期
2023/03/20 15:41:23
分子式
C24H36ClNO2
分子量
406.01
MOL 文件
473268-46-1.mol
473268-46-1 结构式
基本信息
中文别名
化合物 T14126 英文别名
ADDA-5)ADDA 5 HCl
ADDA 5 (ADDA5
ADDA 5 hydrochloride
ADDA 5 hydrochloride >=98% (HPLC)
473268-46-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-U00448 | 473268-46-1 ADDA 5 hydrochloride | 473268-46-1 | 5mg | 910元 |
| 2024/08/19 | HY-U00448 | 473268-46-1 ADDA 5 hydrochloride | 473268-46-1 | 10mM * 1mLin DMSO | 1001元 |
| 2024/08/19 | HY-U00448 | 473268-46-1 ADDA 5 hydrochloride | 473268-46-1 | 10 mg | 1550元 |
常见问题列表
生物活性
ADDA 5 hydrochloride 是一种部分非竞争性的细胞色素 c 氧化酶 (cytochrome c oxidase (CcO)) 抑制剂，可抑制从人胶质瘤细胞和牛心肌细胞中分离纯化的 CcO 的活性，IC50 值分别为 18.93 μM 和 31.82 μM。靶点
IC50: 18.93 μM (CcO, human glioma), 31.82 μM (CcO, bovine heart)
体外研究
ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC 50 s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC 50 s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC 50 of 8.17 μM.
体内研究
ADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice.