475-25-2
中文名称
氧化苏木精
英文名称
HEMATEIN
CAS
475-25-2
分子式
C16H12O6
分子量
300.26
MOL 文件
475-25-2.mol
更新日期
2023/03/20 17:41:19
475-25-2 结构式
基本信息
中文别名
苏木因苏木红
海尔丹
天然黑1
氧化苏木素
氧化苏木精
氧化苏木红
英文别名
hematineHEMATEIN
Hamatein
HAEMATEIN
Hematein,94%
abcolhematinelg
HEMATEIN, STAIN
HYDROXYBRASILEIN
TIMTEC-BB SBB006464
CI75290formicroscopy
物理化学性质
熔点180 °C
沸点361.5°C (rough estimate)
密度1.2766 (rough estimate)
折射率1.4600 (estimate)
储存条件2-8°C
溶解度少许溶于甲醇
色指数75290
酸度系数(pKa)8.02±0.40(Predicted)
形态结晶粉末
颜色深棕色
水溶解性0.6g/L(20 ºC)
Merck13,4651
BRN93039
LogP0.560 (est)
氧化苏木精价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | 37084 | 氧化苏木精 Hematein, Thermo Scientific Chemicals | 475-25-2 | 5g | 718元 |
| 2024/08/19 | 37084 | 氧化苏木精 Hematein, Thermo Scientific Chemicals | 475-25-2 | 25g | 3861元 |
| 2024/04/30 | C37084 | 氧化苏木精 Hematein | 475-25-2 | 5g | 718元 |
常见问题列表
生物活性
Hematein 是苏木精的氧化产物，可作为染料。Hematein 是一种变构酪蛋白激酶 II 抑制剂，IC50 为 0.74 μM。Hematein 抑制 Akt/PKB Ser129 磷酸化，Wnt/TCF 途径并增加肺癌细胞的凋亡。靶点
|
CKII 0.74 μM (IC 50 ) |
Akt
|
Wnt
|
体外研究
Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation.
Cell Viability Assay
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 10-100 μM |
| Incubation Time: | 14 days |
| Result: | Inhibited cells growth. |
Apoptosis Analysis
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 50 and 100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced apoptosis in A427 lung cancer cells. |
Western Blot Analysis
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 50 and 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited CK2-specific Akt phosphorylation. |
体内研究
Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts.
| Animal Model: | Female athymic BALB/c nude mice (6-week-old) |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injections; twice a week for 6 weeks |
| Result: | Inhibited tumor growth in A427 lung cancer cell xenografts. |